SCHEMBL6829609

SCHEMBL6829609

CCOC(=O)CNc1ccc(CNc2cc(OCCCC(=O)O)ccc2NC(C)=O)c(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.40
FFAR4 Q5NUL3 2/20 0.40
RORC P51449 1/20 0.38
POLB P06746 1/20 0.37
MAPT P10636 2/20 0.36
GAA P10253 2/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.36
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
BRD4 O60885 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
PPARA Q07869 1/20 0.35
PPID Q08752 1/20 0.35
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6497406 0.85 BRD4 (0.41) FFAR1FFAR4MAPTLMNAKMT2A
SCHEMBL6489796 0.84 MAPT (0.42) MAPTGAAALDH1A1LMNAKMT2A
SCHEMBL6829611 0.82 FFAR4 (0.39) FFAR1FFAR4MAPTALDH1A1KMT2A
SCHEMBL6489966 0.79 BRD4 (0.37) L3MBTL1BRD4TDP1
SCHEMBL6926026 0.76 ALDH1A1 (0.44) FFAR1FFAR4MAPTGAAALDH1A1
SCHEMBL6496310 0.74 THRB (0.41) GAAKMT2AL3MBTL1
SCHEMBL7070089 0.74 FFAR1 (0.36) FFAR1FFAR4RORCMAPTGAA
SCHEMBL6492219 0.73 DRD2 (0.36)
SCHEMBL6501452 0.73 IDO1 (0.41) MAPTGAAALDH1A1KMT2ABRD4
SCHEMBL6487724 0.73 HDAC1 (0.39) POLBMAPTGAAALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed