Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP4 | Q13115 | 1/20 | 0.42 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018481 | 0.82 | RAB9A (0.39) | CYP3A4RAB9ANPC1ARCYP1A2 | |
| SCHEMBL14829409 | 0.77 | CYP1A2 (0.44) | CYP3A4RAB9ANPC1ARCYP1A2 | |
| SCHEMBL5906927 | 0.77 | AR (0.40) | CYP3A4RAB9ANPC1ARCYP1A2 | |
| SCHEMBL31418349 | 0.75 | RAB9A (0.55) | DUSP4PTP4A1CYP3A4RAB9ANPC1 | |
| SCHEMBL7135049 | 0.74 | ILK (0.39) | RAB9ANPC1TP53MAPTKDM4E | |
| SCHEMBL1404101 | 0.73 | ALDH1A1 (0.59) | CYP3A4RAB9ANPC1ARCYP1A2 | |
| SCHEMBL4179029 | 0.73 | KDM4E (0.58) | CYP3A4RAB9ANPC1CYP1A2CYP2C9 | |
| SCHEMBL2418262 | 0.72 | ITK (0.42) | RAB9ANPC1ARTP53KDM4E | |
| SCHEMBL7107250 | 0.70 | RECQL (0.40) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6482907 | 0.70 | DUSP4 (0.43) | DUSP4PTP4A1CYP3A4RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | DUSP4 3766/4885PTP4A1 4071/4885CYP3A4 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.