Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP4 | Q13115 | 1/20 | 0.43 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31418349 | 0.77 | RAB9A (0.55) | DUSP4PTP4A1METAP2CYP3A4RAB9A | |
| SCHEMBL2345329 | 0.71 | MAPT (0.49) | CYP3A4ARCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6490955 | 0.70 | DUSP4 (0.42) | DUSP4PTP4A1METAP2CYP3A4RAB9A | |
| SCHEMBL17048132 | 0.68 | METAP2 (0.41) | DUSP4PTP4A1METAP2CYP3A4RAB9A | |
| SCHEMBL29660606 | 0.68 | METAP2 (0.54) | METAP2CYP3A4RAB9ANPC1CYP1A2 | |
| SCHEMBL14734857 | 0.68 | METAP2 (0.50) | METAP2CYP3A4CYP2C9KDM4EKMT2A | |
| SCHEMBL321962 | 0.68 | METAP2 (0.54) | METAP2CYP3A4RAB9ANPC1CYP1A2 | |
| SCHEMBL8102439 | 0.67 | RAB9A (0.49) | CYP3A4RAB9ANPC1ARCYP1A2 | |
| Quinoline SCHEMBL9745228 | 0.66 | ALDH1A1 (0.65) | DUSP4PTP4A1METAP2CYP3A4RAB9A | |
| Quinoline SCHEMBL29030603 | 0.64 | ALDH1A1 (0.57) | DUSP4PTP4A1METAP2CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107378-A1 | Heterocyclic amines having central nervous system activity | ROMERO ARTHUR G (US) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107378-A1 | Heterocyclic amines having central nervous system activity | CNR1, CNR2, NPY2R | DUSP4 4579/4885PTP4A1 4410/4885METAP2 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.