Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.42 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16794748 | 1.00 | CA2 (0.50) | CA2MAPK1GPR84FFAR1SLC1A3 | |
| SCHEMBL7186459 | 0.93 | GPR84 (0.57) | CA2MAPK1GPR84FFAR1SLC1A2 | |
| SCHEMBL12920238 | 0.91 | GPR84 (0.61) | GPR84FFAR1SLC1A2SLC1A1MAPT | |
| SCHEMBL4282439 | 0.91 | GPR84 (0.61) | GPR84FFAR1SLC1A2SLC1A1MAPT | |
| SCHEMBL16794740 | 0.91 | GPR84 (0.61) | GPR84FFAR1SLC1A2SLC1A1MAPT | |
| SCHEMBL1333090 | 0.86 | TDP1 (0.50) | CA2MAPK1GPR84FFAR1SLC1A3 | |
| SCHEMBL152526 | 0.85 | CA2 (0.58) | CA2MAPK1GPR84FFAR1SLC1A3 | |
| SCHEMBL3466640 | 0.84 | CA2 (0.52) | CA2MAPK1GPR84FFAR1SLC1A3 | |
| Ammonia Solution, Strong SCHEMBL5355288 | 0.83 | CA2 (0.56) | CA2MAPK1GPR84FFAR1SLC1A3 | |
| Ammonia Solution, Strong SCHEMBL5355285 | 0.83 | CA2 (0.56) | CA2MAPK1GPR84FFAR1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612059-B2 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use | VICURON PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612059-B2 | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use | VICURON PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20090149509-A1 | NOVEL PYRROLIDINE BICYCLIC COMPOUNDS AND ITS DERIVATIVES, COMPOSITIONS AND METHODS OF USE | VICURON PHARMACEUTICALS INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20090149509-A1 | NOVEL PYRROLIDINE BICYCLIC COMPOUNDS AND ITS DERIVATIVES, COMPOSITIONS AND METHODS OF USE | VICURON PHARMACEUTICALS INC. (US) | 2009-06-11 | — | — | US | disclosed |
| US-20050277683-A1 | Novel pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use | VICURON HOLDINGS LLC | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277683-A1 | Novel pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use | PDF, PNPO, PDXK | CA2 4872/4885MAPK1 1844/4885GPR84 4660/4885 |
| US-20090149509-A1 | NOVEL PYRROLIDINE BICYCLIC COMPOUNDS AND ITS DERIVATIVES, COMPOSITIONS AND METHODS OF USE | PDF, PNPO, PDXK | CA2 4872/4885MAPK1 1844/4885GPR84 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.