Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL1747897 | 0.94 | ALDH1A1 (0.40) | ALDH1A1KDM4EGAATEAD1YAP1 | |
| SCHEMBL16292878 | 0.83 | KDM4E (0.38) | ALDH1A1KDM4EGAAHSD17B10TSHR | |
| SCHEMBL5353695 | 0.82 | KDM4E (0.36) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL547449 | 0.82 | KDM4E (0.45) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL7142680 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4EGAATEAD1YAP1 | |
| Hydrochloric Acid SCHEMBL11395268 | 0.80 | LDHA (0.44) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL3383913 | 0.80 | KDM4E (0.35) | ALDH1A1KDM4EGAAHSD17B10TSHR | |
| SCHEMBL826674 | 0.80 | KDM4E (0.35) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL9565260 | 0.80 | KDM4E (0.35) | ALDH1A1KDM4EGAAHSD17B10TSHR | |
| SCHEMBL5309791 | 0.80 | CA12 (0.37) | ALDH1A1KDM4EGAAHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517707-A1 | TREATMENT FOR DEPRESSION AND ANXIETY WITH THE COMBINATION OF A PDE IV INHIBITOR AND AN ANTIDEPRESSANT OR AN ANXIOLYTIC AGENT | Pfizer Products Inc. (US) | 2005-03-30 | — | — | EP | claimed |
| US-20030235631-A1 | Combination treatment for depression and anxiety | PFIZER INC. | 2003-12-25 | — | — | US | claimed |
| WO-2003105902-A1 | TREATMENT FOR DEPRESSION AND ANXIETY BY THE COMBINATION OF A PDE IV INHIBITOR AND AN ANTIDEPRESSANT OR AN ANXIOLYTIC AGENT | PFIZER PRODUCTS INC. (US) | 2003-12-24 | — | — | WO | claimed |
| US-4868195-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | claimed |
| US-20240050363-A1 | VILAZODONE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI YONSUN BIOTECHNOLOGY CO., LTD. (CN) | 2024-02-15 | — | — | US | disclosed |
| EP-4268802-A1 | VILAZODONE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Yonsun Biotechnology Co., Ltd. (CN) | 2023-11-01 | — | — | EP | disclosed |
| CN-112574054-B | Efficient nitriding reagent and application thereof | 北京大学 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022135343-A1 | VILAZODONE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海博志研新药物技术有限公司 | 2022-06-30 | — | — | WO | disclosed |
| CN-113975279-A | Application of vilazodone and derivatives thereof in preparation of antitumor drugs | 复旦大学附属肿瘤医院 | 2022-01-28 | — | — | CN | disclosed |
| CN-112574054-A | Efficient nitriding reagent and application thereof | 北京大学 | 2021-03-30 | — | — | CN | disclosed |
| US-20190002444-A1 | CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-01-03 | — | — | US | disclosed |
| US-10011590-B2 | Crystalline forms of vilazodone hydrochloride and vilazodone free base | DR. REDDY'S LABORATORIES LIMITED (IN) | 2018-07-03 | — | — | US | disclosed |
| US-4921871-A | LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| US-4874758-A | LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-10-17 | — | — | US | disclosed |
| US-4868195-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868200-A | LEUKOTRIENES, LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868205-A | ANTIALLERGENS, ANTIINFLAMMATORY, CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4868199-A | ENZYME INHIBITORS, ANTIALLERGEN, ASTHMA, CARDIOVASCULAR, ANTIINFLAMMATORY | WARNER-LAMBERT COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4761424-A | Enolamides, pharmaceutical compositions and methods for treating inflammation | WARNER-LAMBERT COMPANY (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0221345-A1 | Novel enolamides, process for their manufacture and pharmaceutical compositions thereof with an activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240050363-A1 | VILAZODONE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF | VPS51, VARS1, VMA21 | ALDH1A1 1372/4885KDM4E 1638/4885GAA 1370/4885 |
| US-10011590-B2 | Crystalline forms of vilazodone hydrochloride and vilazodone free base | VIL1, VMA21, PYGL | ALDH1A1 2208/4885KDM4E 1699/4885GAA 464/4885 |
| US-20030235631-A1 | Combination treatment for depression and anxiety | PDE3B, PDE2A, PDE3A | ALDH1A1 281/4885KDM4E 1433/4885GAA 188/4885 |
| US-20190002444-A1 | CRYSTALLINE FORMS OF VILAZODONE HYDROCHLORIDE AND VILAZODONE FREE BASE | VIL1, VMA21, PYGL | ALDH1A1 2208/4885KDM4E 1699/4885GAA 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.