Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 19/20 | 0.49 |
| ▸ | ITGAV | P06756 | 19/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 19/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506524 | 0.91 | ITGB3 (0.40) | ITGB3ITGAVITGA2B | |
| SCHEMBL3039366 | 0.87 | ITGB3 (0.40) | ITGB3ITGAVITGA2B | |
| SCHEMBL6495597 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVITGA2B | |
| SCHEMBL6494288 | 0.87 | ITGB3 (0.52) | ITGB3ITGAVITGA2BADAMTS4MMP2 | |
| SCHEMBL6503005 | 0.86 | ITGB3 (0.51) | ITGB3ITGAVITGA2BADAMTS4 | |
| SCHEMBL14431276 | 0.81 | ITGB3 (0.39) | ITGB3ITGAVITGA2B | |
| SCHEMBL3046466 | 0.81 | ITGB3 (0.39) | ITGB3ITGAVITGA2B | |
| SCHEMBL6504314 | 0.78 | ITGB3 (0.44) | ITGB3ITGAVITGA2B | |
| SCHEMBL5204669 | 0.78 | ITGB1 (0.49) | ITGB3ITGAVITGA2B | |
| SCHEMBL3041592 | 0.77 | ITGB3 (0.53) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |