Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.51 |
| ▸ | ITGAV | P06756 | 11/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504314 | 0.91 | ITGB3 (0.44) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL6505393 | 0.89 | ITGB3 (0.42) | ITGB3ITGAVITGB1ITGA5ALPL | |
| SCHEMBL6495002 | 0.89 | ITGB3 (0.41) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL6505728 | 0.86 | ITGB3 (0.49) | ITGB3ITGAVADAMTS4ITGA2B | |
| SCHEMBL3048231 | 0.83 | ITGB3 (0.45) | ITGB3ITGAVITGB1ITGA5PTPN1 | |
| SCHEMBL6494288 | 0.82 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGA5ADAMTS4 | |
| SCHEMBL14431792 | 0.79 | BCHE (0.37) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL6506524 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGB1ITGA5ITGA2B | |
| SCHEMBL5204539 | 0.78 | ITGB3 (0.41) | ITGB3ITGAVITGB1ITGA5PTPN1 | |
| SCHEMBL6495597 | 0.74 | ITGB3 (0.39) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |