Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 11/20 | 0.56 |
| ▸ | IMPDH1 | P20839 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484655 | 0.87 | IMPDH2 (0.64) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6485457 | 0.83 | IMPDH2 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL7543123 | 0.80 | NPC1 (0.56) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL27561214 | 0.78 | IMPDH2 (0.64) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6497151 | 0.73 | IMPDH2 (1.00) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL14027190 | 0.70 | KMT2A (0.76) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6493937 | 0.70 | IMPDH2 (0.52) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL6485360 | 0.69 | IMPDH2 (0.68) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL15742655 | 0.69 | PORCN (0.58) | IMPDH2IMPDH1NPC1RAB9AKDM4E | |
| SCHEMBL5913093 | 0.69 | MEN1 (0.44) | NPC1RAB9AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |