Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.48 |
| ▸ | TUBB | P07437 | 5/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28285243 | 0.86 | ALDH1A1 (0.65) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL5438097 | 0.84 | NR4A2 (0.69) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL6493095 | 0.81 | TLR8 (0.43) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL28435543 | 0.80 | NR4A2 (0.63) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL14564439 | 0.80 | KIF11 (0.56) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL10314414 | 0.78 | MDM4 (0.46) | MEN1KMT2ALMNATUBB4ATUBB | |
| SCHEMBL14709940 | 0.76 | NR4A2 (0.61) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL26031834 | 0.74 | NR4A2 (0.59) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL7653286 | 0.73 | NR4A2 (0.68) | NR4A2KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL31312750 | 0.73 | TUBB4A (0.62) | NR4A2KDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075499-A1 | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy | AGOURON PHARMACEUTICALS, INC. | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075499-A1 | Tricyclic compounds protein kinase inhibitors for enhancing the efficacy of anti-neoplastic agents and radiation therapy | CHEK2, CHEK1, CHKA | NR4A2 2235/4885KDM4E 1654/4885MEN1 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.