Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GRM8 | O00222 | 3/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.45 |
| ▸ | GRM6 | O15303 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503380 | 0.82 | TTR (0.49) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL29192875 | 0.75 | GRM8 (0.52) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL12089924 | 0.74 | ALDH1A1 (0.53) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL3866115 | 0.74 | AKR1C3 (0.57) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL31480976 | 0.74 | AKR1C3 (0.57) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL31347515 | 0.73 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL31584827 | 0.73 | ALDH1A1 (0.51) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL7978440 | 0.73 | GRM8 (0.54) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL7245339 | 0.73 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4TSHRKMT2A | |
| SCHEMBL31481066 | 0.73 | ALDH1A1 (0.56) | ALDH1A1TDP1CYP3A4TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858739-B2 | Indole and benzimidazole 15-lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-02-22 | — | — | US | disclosed |
| US-20040038943-A1 | Indole and benzimidazole 15-lipoxygenase inhibitors | CONNOR DAVID THOMAS (US) | 2004-02-26 | — | — | US | disclosed |
| EP-1294686-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096299-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038943-A1 | Indole and benzimidazole 15-lipoxygenase inhibitors | ALOX15, ALOX5, ALOX12 | ALDH1A1 470/4885TDP1 2987/4885CYP3A4 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.