Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.65 |
| ▸ | PTGES | O14684 | 5/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505812 | 0.89 | ALOX5 (0.72) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6626514 | 0.83 | ALOX5 (0.64) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494104 | 0.80 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6497004 | 0.79 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494193 | 0.77 | ALOX5 (0.72) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6486937 | 0.74 | PTGES (0.58) | ALOX5PTGS1PTGESSLC6A3 | |
| SCHEMBL6484148 | 0.74 | PTGES (0.58) | ALOX5PTGS1PTGESSLC6A3 | |
| SCHEMBL6503323 | 0.70 | PTGS1 (0.62) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL28369714 | 0.70 | GABRA1 (0.50) | MAPK8TP53 | |
| SCHEMBL6495841 | 0.67 | ALOX5 (0.74) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |