Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.55 |
| ▸ | PTGES | O14684 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494104 | 0.76 | ALOX5 (1.00) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6494193 | 0.76 | ALOX5 (0.72) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6505812 | 0.73 | ALOX5 (0.72) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL1839904 | 0.73 | PTGES (0.52) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6497004 | 0.71 | ALOX5 (1.00) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6498777 | 0.70 | PTGS1 (0.46) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6187785 | 0.70 | PTGS1 (0.43) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6496569 | 0.70 | ALOX5 (0.66) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6626514 | 0.69 | ALOX5 (0.64) | PTGS1ALOX5PTGS2PTGESALOX5AP | |
| SCHEMBL6476564 | 0.65 | PTGS2 (0.68) | PTGS1ALOX5PTGS2PTGESLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |
| US-20050009843-A1 | Medicine for inhibiting drug elimination pump | TRINE PHARMACEUTICALS, INC. | 2005-01-13 | — | — | US | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1232158-B1 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009843-A1 | Medicine for inhibiting drug elimination pump | ABCB11, ATP6AP1, HRH2 | PTGS1 604/4885ALOX5 128/4885PTGS2 1242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.