Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946061 | 0.81 | LMNA (0.59) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL137254 | 0.81 | LMNA (0.59) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL9018864 | 0.79 | PKM (0.53) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL11554950 | 0.79 | PKM (0.53) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL5255044 | 0.79 | PKM (0.53) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL2104344 | 0.79 | PKM (0.49) | PKMLMNAL3MBTL1KDM4ENPC1 | |
| SCHEMBL1760632 | 0.78 | KMT2A (0.58) | LMNAL3MBTL1NPC1RAB9AKMT2A | |
| SCHEMBL6503488 | 0.78 | NPSR1 (0.56) | L3MBTL1NPC1RAB9AKMT2AHTT | |
| SCHEMBL17460946 | 0.78 | HTT (0.62) | PKMKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2512409 | 0.78 | MLYCD (0.65) | PKMKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |