Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 8/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948241 | 0.84 | ESR1 (0.54) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL131719 | 0.77 | TSHR (0.60) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL11085145 | 0.76 | GAA (0.47) | TSHRALDH1A1HSD17B10MAPTRAB9A | |
| SCHEMBL7297972 | 0.74 | STS (0.44) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL6950385 | 0.74 | LMNA (0.53) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL7734044 | 0.74 | TSHR (0.65) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL11109738 | 0.73 | ALDH1A1 (0.68) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL5137750 | 0.73 | ALDH1A1 (0.68) | TSHRCYP3A4LMNACYP1A2CYP2C19 | |
| SCHEMBL4630359 | 0.73 | TSHR (0.61) | TSHRCYP3A4LMNAALDH1A1HSD17B10 | |
| SCHEMBL5175629 | 0.73 | CYP1A2 (0.67) | TSHRCYP3A4LMNACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6909005-B1 | One post synthesis of 2-oxazolidinone derivatives | ASTRAZENECA UK LIMITED (GB) | 2005-06-21 | — | — | US | disclosed |