Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948241 | 0.91 | ESR1 (0.54) | LMNAESR1TSHRTDP1STS | |
| SCHEMBL128776 | 0.87 | CA12 (0.53) | LMNAALDH1A1ESR1TSHRKDM4E | |
| SCHEMBL11331870 | 0.81 | KDM4E (0.55) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL6950073 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4EJMJD6MAPT | |
| SCHEMBL132053 | 0.78 | LMNA (0.67) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL130905 | 0.77 | ALDH1A1 (0.58) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL111664 | 0.75 | LMNA (0.75) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL6953920 | 0.75 | ALDH1A1 (0.57) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL49950 | 0.74 | ALDH1A1 (0.84) | LMNAALDH1A1ESR1TSHRCHRM1 | |
| SCHEMBL12756270 | 0.74 | LMNA (0.67) | LMNAALDH1A1ESR1TSHRCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |