Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504972 | 0.89 | OPRM1 (0.68) | OPRM1DRD2DRD4OPRK1OPRL1 | |
| SCHEMBL7068005 | 0.87 | OPRM1 (0.84) | OPRM1DRD2DRD4CCR8OPRK1 | |
| SCHEMBL20763327 | 0.84 | OPRM1 (0.81) | OPRM1DRD2DRD4OPRK1OPRL1 | |
| SCHEMBL6498522 | 0.84 | OPRM1 (0.74) | OPRM1DRD2DRD4OPRK1OPRD1 | |
| SCHEMBL7066463 | 0.81 | CYP3A4 (0.62) | OPRM1DRD2DRD4CCR8OPRL1 | |
| SCHEMBL6497509 | 0.81 | OPRM1 (0.82) | OPRM1DRD2DRD4OPRK1OPRD1 | |
| SCHEMBL6507423 | 0.81 | OPRM1 (0.75) | OPRM1DRD2DRD4OPRK1OPRD1 | |
| SCHEMBL7070692 | 0.79 | OPRM1 (0.57) | OPRM1DRD2DRD4CCR8OPRK1 | |
| SCHEMBL20763442 | 0.79 | OPRM1 (0.76) | OPRM1DRD2DRD4OPRK1OPRL1 | |
| SCHEMBL6503296 | 0.78 | OPRM1 (0.73) | OPRM1DRD2DRD4OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | OPRM1 494/4885DRD2 3014/4885DRD4 3663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.