Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 9/20 | 0.41 |
| ▸ | CA1 | P00915 | 7/20 | 0.41 |
| ▸ | CA2 | P00918 | 7/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500903 | 0.84 | IRAK4 (0.41) | ABCC9ABCC8KCNJ11KCNJ8IRAK4 | |
| SCHEMBL6468270 | 0.82 | CA9 (0.48) | KDM4EIRAK4CA9CA1CA2 | |
| SCHEMBL6505306 | 0.81 | CA12 (0.42) | KDM4EPKMABCC9ABCC8KCNJ11 | |
| SCHEMBL6508306 | 0.81 | CA9 (0.54) | CA9CA1CA2CA12 | |
| SCHEMBL6467588 | 0.80 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11KCNJ8IRAK4 | |
| SCHEMBL6470265 | 0.79 | ITK (0.42) | KDM4EABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6500553 | 0.77 | IRAK4 (0.41) | KDM4EIRAK4CA9CA1CA2 | |
| SCHEMBL6469492 | 0.77 | IRAK4 (0.42) | KDM4EPKMIRAK4ITK | |
| SCHEMBL6497388 | 0.76 | KDM4E (0.53) | KDM4EIRAK4CA9CA1CA2 | |
| SCHEMBL6465833 | 0.75 | ALDH1A1 (0.53) | KDM4EPKMIRAK4CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | KDM4E 2424/4885PKM 2290/4885ABCC9 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.