Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501912 | 0.82 | ITK (0.52) | PARP1MDM2RIPK1CFD | |
| SCHEMBL14692432 | 0.76 | NOTUM (0.50) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL15933232 | 0.75 | NOTUM (0.43) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL3574293 | 0.73 | PARP1 (0.58) | PARP1NOTUMIKBKB | |
| Potassium SCHEMBL6498895 | 0.73 | RIPK1 (0.45) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL6498887 | 0.73 | RIPK1 (0.45) | PARP1MDM2NOTUMRIPK1IDO1 | |
| Potassium Ion SCHEMBL6498890 | 0.72 | RIPK1 (0.42) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL15930151 | 0.72 | NOTUM (0.41) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL14692524 | 0.71 | NOTUM (0.51) | PARP1MDM2NOTUMRIPK1IDO1 | |
| SCHEMBL6505228 | 0.71 | KDM4E (0.55) | PARP1NOTUMIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | PARP1 1904/4885MDM2 1189/4885NOTUM 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.