Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500307 | 0.90 | MAPT (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2GLA | |
| SCHEMBL6472225 | 0.85 | KMO (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6508388 | 0.84 | ITK (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6470632 | 0.83 | ITK (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6499042 | 0.83 | KDM4E (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6506090 | 0.82 | IRAK4 (0.44) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6498382 | 0.81 | ITK (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2NFKB1 | |
| SCHEMBL6505547 | 0.81 | IRAK4 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6497388 | 0.81 | KDM4E (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6506609 | 0.80 | ITK (0.49) | ALDH1A1SMN1; SMN2MAPTKDM4EITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | NPC1 3546/4885RAB9A 2534/4885ALDH1A1 846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.