Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 20/20 | 0.62 |
| ▸ | MMP1 | P03956 | 19/20 | 0.62 |
| ▸ | MMP9 | P14780 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626726 | 0.85 | ADAM17 (0.84) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6508443 | 0.85 | MMP13 (0.84) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6506632 | 0.81 | MMP13 (0.80) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6506359 | 0.81 | MMP13 (0.71) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL7442494 | 0.81 | MMP13 (0.69) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6500455 | 0.80 | MMP13 (0.82) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6501341 | 0.80 | ADAM17 (0.64) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6506731 | 0.80 | MMP13 (0.80) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL7429732 | 0.79 | MMP1 (0.62) | MMP13ADAM17MMP1MMP9 | |
| SCHEMBL6506041 | 0.78 | MMP13 (0.80) | MMP13ADAM17MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH HOLDINGS CORPORATION | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, MMP12 | MMP13 115/4885ADAM17 30/4885MMP1 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.