Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469868 | 0.86 | IRAK4 (0.54) | ITKSCN9AIRAK4CHEK1TP53 | |
| Trifluoroacetic Acid SCHEMBL6466204 | 0.85 | ITK (0.47) | ITKL3MBTL1MAPTNPC1ALDH1A1 | |
| SCHEMBL6467527 | 0.82 | KDM4E (0.47) | ITKIRAK4TP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL6504903 | 0.81 | KMT2A (0.49) | SMN1; SMN2EPHX2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL6500092 | 0.80 | KDM4E (0.47) | ITKTP53SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL6465833 | 0.79 | ALDH1A1 (0.53) | ITKIRAK4L3MBTL1MAPTKDM4E | |
| SCHEMBL6466511 | 0.79 | ITK (0.44) | ITKIRAK4TP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL6469788 | 0.79 | KMT2A (0.46) | ITKIRAK4SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL6469794 | 0.79 | LMNA (0.47) | ITKSMN1; SMN2CDK8KDM4ENPC1 | |
| SCHEMBL6506767 | 0.79 | ITK (0.48) | ITKTP53SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885SCN9A 4159/4885IRAK4 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.