Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491506 | 0.81 | TRPA1 (0.46) | NPC1METAP2RAB9AHPGD | |
| SCHEMBL6491692 | 0.80 | PARP1 (0.45) | NPC1AURKAMETAP2RAB9AMAP2K1 | |
| SCHEMBL19100359 | 0.76 | METTL3 (0.58) | MEN1KMT2AMAPTCYP1A2NPC1 | |
| SCHEMBL4155814 | 0.75 | ALDH1A1 (0.50) | JAK2JAK3MEN1KMT2AMAPT | |
| SCHEMBL20973053 | 0.74 | MEN1 (0.51) | MEN1KMT2AMAPTNPC1KDM4E | |
| SCHEMBL22730639 | 0.71 | ALOX5 (0.53) | JAK2JAK3KMT2AMAPTNPC1 | |
| SCHEMBL24074556 | 0.71 | MAPT (0.60) | MAPTCYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL22886579 | 0.70 | BRAF (0.52) | MEN1KMT2ANPC1KDM4EALDH1A1 | |
| SCHEMBL11577717 | 0.70 | KMT2A (0.56) | MEN1KMT2AMAPTNPC1KDM4E | |
| SCHEMBL830035 | 0.70 | ALDH1A1 (0.59) | MEN1KMT2AMAPTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897231-B2 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, INC. (US) | 2005-05-24 | — | — | US | disclosed |