Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500197 | 0.90 | HTT (0.43) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| SCHEMBL6501378 | 0.83 | RAB9A (0.44) | SMN1; SMN2LMNATSHRALDH1A1NPC1 | |
| SCHEMBL6061470 | 0.77 | HTR2A (0.47) | LMNAALDH1A1HSD17B10THRATHRB | |
| SCHEMBL346623 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| SCHEMBL6504970 | 0.74 | CYP19A1 (0.39) | SMN1; SMN2LMNAHTTNPC1RAB9A | |
| SCHEMBL17241692 | 0.73 | ALDH1A1 (0.44) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| Fluoride SCHEMBL29251977 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| Bromide SCHEMBL547143 | 0.73 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| SCHEMBL27861065 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| SCHEMBL27037085 | 0.72 | MAPK1 (0.48) | SMN1; SMN2LMNATSHRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | SMN1; SMN2 4112/4885LMNA 3321/4885HTT 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.