Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127775 | 0.78 | PGR (0.44) | PGRCASP3 | |
| SCHEMBL7407725 | 0.78 | PGR (0.44) | MAPK14PGRCASP3 | |
| SCHEMBL28813679 | 0.78 | PGR (0.47) | PGRCASP3 | |
| SCHEMBL1895888 | 0.77 | CASP3 (0.56) | PTGS2PGRCASP3 | |
| SCHEMBL10843937 | 0.76 | MAPK14 (0.79) | MAPK14PTGS1PTGS2 | |
| SCHEMBL9773297 | 0.75 | RAB9A (0.47) | PGRCASP3 | |
| SCHEMBL4197618 | 0.74 | MAPK14 (0.50) | MAPK14PTGS1PTGS2 | |
| SCHEMBL693906 | 0.74 | CYP2A6 (0.59) | MAPK14PTGS1PTGS2 | |
| SCHEMBL5561057 | 0.74 | ESR1 (0.47) | MAPK14PTGS1PGRCASP3 | |
| SCHEMBL29085013 | 0.74 | HSD17B1 (0.47) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102464667-B | Five-membered heterocycle pyrimidine compounds, preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2014-06-04 | — | — | CN | disclosed |
| CN-102464667-A | Five-membered heterocyclic pyrimidine compounds, preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2012-05-23 | — | — | CN | disclosed |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | MAPK14 3292/4885PTGS1 63/4885PTGS2 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.