Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 5/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 3/20 | 1.00 |
| ▸ | PTGES | O14684 | 5/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495841 | 0.84 | ALOX5 (0.74) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494870 | 0.82 | ALOX5 (0.70) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495009 | 0.82 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503974 | 0.71 | ALOX5 (0.81) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL10026721 | 0.70 | PTGES (0.65) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6502937 | 0.69 | ALOX5 (0.55) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6494104 | 0.68 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6498829 | 0.68 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503718 | 0.68 | ALOX5 (0.53) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6622141 | 0.67 | ALOX5 (0.52) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |