Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 4/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.69 |
| ▸ | PTGES | O14684 | 2/20 | 0.61 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503974 | 0.90 | ALOX5 (0.81) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6498829 | 0.87 | ALOX5 (0.77) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505084 | 0.86 | ALOX5 (0.76) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495841 | 0.85 | ALOX5 (0.74) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503480 | 0.82 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505363 | 0.79 | ALOX5 (0.66) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505366 | 0.79 | ALOX5 (0.66) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| Licofelone SCHEMBL237833 | 0.76 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6497004 | 0.75 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6206054 | 0.74 | ALOX5 (0.69) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261269-A1 | New derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them | SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) | 2005-11-24 | — | — | US | claimed |
| US-6949615-B2 | Monomer having electron-withdrawing group and process for preparing the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1232158-B1 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1331216-A1 | MONOMERS HAVING ELECTRON-WITHDRAWING GROUPS AND PROCESSES FOR PREPARING THE SAME | Daicel Chemical Industries, Ltd. (JP) | 2003-07-30 | — | — | EP | disclosed |
| US-20030059710-A1 | Monomer having electron-withdrawing group and process for preparing the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261269-A1 | New derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them | NOS2, NOS1, NOS3 | ALOX5 259/4885PTGS1 75/4885PTGS2 87/4885 |
| US-20030059710-A1 | Monomer having electron-withdrawing group and process for preparing the same | RFC3, RFC2, MAPRE1 | ALOX5 4139/4885PTGS1 3402/4885PTGS2 3314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.