Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGES | O14684 | 6/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626514 | 0.81 | ALOX5 (0.64) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6506451 | 0.81 | ALOX5 (0.53) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505084 | 0.78 | ALOX5 (0.76) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6499123 | 0.75 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL7000442 | 0.73 | PTGES (0.56) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6993174 | 0.73 | PTGES (0.56) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495841 | 0.70 | ALOX5 (0.74) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495009 | 0.69 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503718 | 0.68 | ALOX5 (0.53) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503480 | 0.67 | ALOX5 (1.00) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1232158-B1 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |