Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | LGMN | Q99538 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29838655 | 0.86 | LGMN (0.61) | LGMNTSHRALDH1A1RECQLTDP1 | |
| SCHEMBL16933549 | 0.85 | LGMN (0.56) | LGMNTSHRALDH1A1RECQLTDP1 | |
| SCHEMBL6510215 | 0.85 | F10 (0.56) | CCR8LGMNALDH1A1RECQLTDP1 | |
| SCHEMBL13896504 | 0.83 | ALDH1A1 (0.69) | CCR8LGMNTSHRALDH1A1TDP1 | |
| SCHEMBL6502769 | 0.83 | SCN9A (0.59) | PARP10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6507338 | 0.83 | LGMN (0.49) | LGMNTSHRALDH1A1RECQLTDP1 | |
| SCHEMBL1749330 | 0.83 | MAPT (0.68) | LGMNTSHRALDH1A1RECQLTDP1 | |
| SCHEMBL6507177 | 0.82 | NOTUM (0.64) | CCR8LGMNALDH1A1PDK2MAPT | |
| SCHEMBL6502658 | 0.81 | LGMN (0.64) | LGMNTSHRALDH1A1PDK2MAPT | |
| SCHEMBL8639296 | 0.80 | ALDH1A1 (0.56) | CCR8PARP10TSHRALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |