Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506047 | 0.87 | NOTUM (0.57) | NOTUM | |
| SCHEMBL6503652 | 0.83 | CCR8 (0.59) | LGMNALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL6526867 | 0.83 | NOTUM (0.62) | LGMNALDH1A1MEN1KMT2APDK2 | |
| SCHEMBL29838655 | 0.81 | LGMN (0.61) | LGMNALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL16933549 | 0.80 | LGMN (0.56) | LGMNALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL6510215 | 0.80 | F10 (0.56) | LGMNALDH1A1RECQLPDK2TDP1 | |
| SCHEMBL1749330 | 0.78 | MAPT (0.68) | LGMNALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL13896504 | 0.76 | ALDH1A1 (0.69) | LGMNALDH1A1MEN1GAAKMT2A | |
| SCHEMBL6502658 | 0.76 | LGMN (0.64) | LGMNALDH1A1MEN1KMT2APDK2 | |
| SCHEMBL16649043 | 0.75 | MAPT (0.61) | LGMNALDH1A1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077368-A2 | TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | claimed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |