SCHEMBL6503787

SCHEMBL6503787

COCc1cnc(Cn2c(C)nc3c(C)cc(OCc4cccc(C)c4C(=O)O)cc32)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PIK3C2B O00750 5/20 0.38
DCTPP1 Q9H773 3/20 0.35
BCL2 P10415 4/20 0.34
MCL1 Q07820 4/20 0.34
PIK3CB P42338 2/20 0.34
MRGPRX4 Q96LA9 2/20 0.34
ALOX5AP P20292 1/20 0.34
PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6500609 0.93 DCTPP1 (0.38) PIK3C2BDCTPP1BCL2MCL1ALOX5AP
SCHEMBL6491725 0.92 PIK3C2B (0.37) PIK3C2BDCTPP1BCL2MCL1PIK3CB
SCHEMBL6488928 0.90 BCL2 (0.44) PIK3C2BBCL2MCL1
SCHEMBL6501064 0.90 PIK3C2B (0.38) PIK3C2BDCTPP1BCL2MCL1PIK3CB
SCHEMBL6487607 0.88 REN (0.38) PIK3C2BDCTPP1BCL2MCL1PIK3CB
SCHEMBL6499279 0.86 BCL2 (0.38) PIK3C2BDCTPP1BCL2MCL1
SCHEMBL6492991 0.86 DCTPP1 (0.36) PIK3C2BDCTPP1BCL2MCL1
SCHEMBL6489544 0.83 BCL2 (0.45) PIK3C2BBCL2MCL1
SCHEMBL7191818 0.82 DCTPP1 (0.35) PIK3C2BDCTPP1ALOX5AP
SCHEMBL6492258 0.81 ALDH1A1 (0.35) PIK3C2BDCTPP1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD PIK3C2B 2433/4885DCTPP1 1534/4885BCL2 774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.