Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 8/20 | 0.47 |
| ▸ | PRKACA | P17612 | 5/20 | 0.47 |
| ▸ | GSK3A | P49840 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | PRKX | P51817 | 4/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | AKT2 | P31751 | 3/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.47 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.47 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515778 | 0.87 | CHRM2 (0.48) | CHRM2CHRM1CHRM3 | |
| SCHEMBL1515839 | 0.85 | KCNA5 (0.47) | CYP2D6CYP3A4CYP2C9CYP19A1CYP11B1 | |
| SCHEMBL4828431 | 0.84 | AKR1C3 (0.47) | CYP2D6CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL5319843 | 0.82 | CYP17A1 (0.53) | MAPK1CYP2D6CYP3A4CYP2C9CYP19A1 | |
| SCHEMBL7450991 | 0.82 | CHRM2 (0.47) | CHRM2CHRM1CHRM3 | |
| SCHEMBL1515892 | 0.82 | NFE2L2 (0.49) | NFE2L2CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL6510105 | 0.80 | MAPKAPK2 (0.44) | ROCK2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6508159 | 0.77 | ALDH1A1 (0.47) | CYP2D6CYP2C9CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL23882848 | 0.76 | ROCK1 (0.50) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL4025059 | 0.76 | AOC3 (0.51) | ROCK2ROCK1PRKG1PRKACAGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080113-A1 | Medicinal compositions | TNF, TRAF6, MMP8 | ROCK2 102/4885ROCK1 53/4885PRKG1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.