Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504966 | 0.92 | OPRM1 (0.70) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6161133 | 0.91 | CHRM1 (0.92) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6496007 | 0.89 | OPRM1 (0.83) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6505610 | 0.86 | OPRM1 (0.68) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL7070238 | 0.85 | OPRM1 (0.65) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6507099 | 0.85 | OPRM1 (0.65) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6497550 | 0.85 | OPRM1 (0.67) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6504972 | 0.83 | OPRM1 (0.68) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL8884316 | 0.82 | OPRM1 (0.78) | CHRM1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL6498522 | 0.82 | OPRM1 (0.74) | CHRM1OPRM1OPRK1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| US-20050009843-A1 | Medicine for inhibiting drug elimination pump | TRINE PHARMACEUTICALS, INC. | 2005-01-13 | — | — | US | disclosed |
| EP-1389463-A1 | MEDICINE FOR INHIBITING DRUG ELIMINATION PUMP | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | CHRM1 2534/4885OPRM1 494/4885OPRK1 246/4885 |
| US-20050009843-A1 | Medicine for inhibiting drug elimination pump | ABCB11, ATP6AP1, HRH2 | CHRM1 51/4885OPRM1 82/4885OPRK1 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.