Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 12/20 | 0.74 |
| ▸ | SLC6A4 known ✓ | P31645 | 12/20 | 0.74 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 12/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.74 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6504303 | 1.00 | NOS2 (0.74) | NOS2SLC6A2SLC6A4CYP2D6TAS2R14 | |
| SCHEMBL6495015 | 0.92 | SLC6A2 (0.70) | NOS2SLC6A2SLC6A4CYP2D6TAS2R14 | |
| Fumaric Acid SCHEMBL6494416 | 0.85 | NOS2 (1.00) | NOS2SLC6A2SLC6A4CYP2D6KCNH2 | |
| Fumaric Acid SCHEMBL6494424 | 0.85 | NOS2 (1.00) | NOS2SLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL6505773 | 0.76 | NOS2 (1.00) | NOS2SLC6A2SLC6A4CYP2D6KCNH2 | |
| Oxalic Acid SCHEMBL6491750 | 0.71 | NOS2 (0.72) | NOS2SLC6A2SLC6A4CYP2D6SLC6A3 | |
| SCHEMBL6503738 | 0.68 | SLC6A2 (0.74) | NOS2SLC6A2SLC6A4CYP2D6SLC6A3 | |
| Fumaric Acid SCHEMBL6490624 | 0.67 | NOS2 (0.47) | NOS2SLC6A2SLC6A4CYP2D6TAS2R14 | |
| Fumaric Acid SCHEMBL6490629 | 0.67 | NOS2 (0.47) | NOS2SLC6A2SLC6A4CYP2D6TAS2R14 | |
| Fumaric Acid SCHEMBL6579132 | 0.67 | TAS2R14 (0.41) | NOS2SLC6A2SLC6A4CYP2D6TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953797-B2 | Use of phenylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2005-10-11 | — | — | US | disclosed |
| US-20030073685-A1 | Novel use of phenylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073685-A1 | Novel use of phenylheteroalkylamine derivatives | CYP1A1, CYP1A2, CYP2E1 | SLC6A2 1769/4885SLC6A4 1977/4885SLC6A3 2703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.