Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19353774 | 0.87 | CYP3A4 (0.50) | NPC1RAB9AHSD17B10FLT1CDK8 | |
| SCHEMBL6499258 | 0.86 | MAPKAPK2 (0.47) | MAPKAPK2CNR1HSD11B1NPC1RAB9A | |
| SCHEMBL27657223 | 0.83 | MAPKAPK2 (0.45) | MAPKAPK2CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL5594919 | 0.80 | HSD11B1 (0.51) | MAPKAPK2HSD11B1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL28302004 | 0.79 | MAPKAPK2 (0.53) | MAPKAPK2HSD17B10CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL12797926 | 0.77 | FLT1 (0.45) | NPC1RAB9AHPGDHSD17B10FLT1 | |
| SCHEMBL12797931 | 0.77 | FLT1 (0.49) | NPC1RAB9AHPGDHSD17B10FLT1 | |
| SCHEMBL5319319 | 0.76 | MAPKAPK2 (0.60) | MAPKAPK2MEN1KMT2AALDH1A1MAPK9 | |
| SCHEMBL6528504 | 0.76 | HSD11B1 (0.51) | MAPKAPK2CNR1HSD11B1MEN1KMT2A | |
| SCHEMBL1073638 | 0.74 | ALDH1A1 (0.61) | MAPKAPK2HSD11B1CYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256167-A1 | Preparation and use of imidazole derivatives for treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256167-A1 | Preparation and use of imidazole derivatives for treatment of obesity | GPR119, GIPR, PGC | MAPKAPK2 1042/4885CNR1 405/4885HSD11B1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.