Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 10/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533612 | 0.92 | ITK (0.41) | ITKPARP1HIF1AEPAS1ALDH1A1 | |
| SCHEMBL6469794 | 0.83 | LMNA (0.47) | ITKKDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6506596 | 0.82 | KDM4E (0.41) | ITKPARP1PARP2PARP3KDM4E | |
| SCHEMBL6506767 | 0.82 | ITK (0.48) | ITKPARP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL6467527 | 0.80 | KDM4E (0.47) | ITKPARP1KDM4ESMN1; SMN2HTT | |
| SCHEMBL6469788 | 0.80 | KMT2A (0.46) | ITKKDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6465833 | 0.80 | ALDH1A1 (0.53) | ITKPARP1PARP2PARP3KDM4E | |
| SCHEMBL6466511 | 0.80 | ITK (0.44) | ITKPARP1PARP2PARP3KDM4E | |
| SCHEMBL6498196 | 0.80 | ITK (0.42) | ITKPARP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6469937 | 0.80 | ITK (0.49) | ITKPARP1PARP2PARP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885PARP1 1904/4885PARP2 1481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.