Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 16/20 | 0.40 |
| ▸ | ITGAV | P06756 | 16/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505728 | 0.91 | ITGB3 (0.49) | ITGB3ITGA2BITGAV | |
| SCHEMBL6495597 | 0.89 | ITGB3 (0.39) | ITGB3ITGA2BITGAV | |
| SCHEMBL3039366 | 0.89 | ITGB3 (0.40) | ITGB3ITGA2BITGAV | |
| SCHEMBL5204669 | 0.87 | ITGB1 (0.49) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6504314 | 0.87 | ITGB3 (0.44) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL14431276 | 0.79 | ITGB3 (0.39) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL3046466 | 0.79 | ITGB3 (0.39) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6495002 | 0.78 | ITGB3 (0.41) | ITGB3ITGA2BITGAVITGB1ITGA5 | |
| SCHEMBL6505393 | 0.78 | ITGB3 (0.42) | ITGB3ITGAVITGB1ITGA5 | |
| SCHEMBL5204428 | 0.78 | ITGB1 (0.47) | ITGB3ITGA2BITGAVITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849646-B1 | Chromenone and chromanone derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2005-02-01 | — | — | US | disclosed |
| EP-1124824-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026212-A1 | CHROMENONE AND CHROMANONE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2000-05-11 | — | — | WO | disclosed |