Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGG1 | O15527 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 6/20 | 0.49 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16210507 | 0.78 | F10 (0.70) | OGG1HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL6506008 | 0.78 | IKBKB (0.56) | HDAC6NPC1RAB9AMEN1HPGD | |
| SCHEMBL6507659 | 0.76 | IKBKB (0.53) | HDAC1HDAC8HDAC6MAPTSMN1; SMN2 | |
| SCHEMBL6510323 | 0.75 | HDAC1 (0.52) | HDAC1HDAC8HDAC6RAB9AMEN1 | |
| SCHEMBL6530279 | 0.74 | IKBKB (0.48) | HDAC6MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6504891 | 0.74 | IKBKB (0.57) | HDAC6SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL6506340 | 0.74 | FLT3 (0.51) | HDAC6MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5224540 | 0.74 | PRSS12 (0.60) | OGG1HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL7675240 | 0.72 | MCL1 (0.71) | OGG1HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL6506347 | 0.72 | IKBKB (0.61) | HDAC6MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |