Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510229 | 0.87 | IRAK4 (0.39) | HTTKMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6469788 | 0.87 | KMT2A (0.46) | HTTMEN1KMT2ACA12CA9 | |
| SCHEMBL6468154 | 0.85 | SMN1; SMN2 (0.50) | HTTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6500414 | 0.85 | MAPKAPK2 (0.45) | HTTALDH1A1SMN1; SMN2KDM4EIRAK4 | |
| SCHEMBL6499185 | 0.80 | ALDH1A1 (0.37) | HTTMEN1KMT2ACA1CA2 | |
| SCHEMBL6469794 | 0.76 | LMNA (0.47) | HTTMEN1KMT2ACA12CA9 | |
| SCHEMBL6470229 | 0.75 | CA9 (0.47) | HTTMEN1KMT2ACA12CA9 | |
| SCHEMBL6505259 | 0.74 | KDM4E (0.44) | ALDH1A1SMN1; SMN2KDM4EIRAK4ITK | |
| SCHEMBL6466511 | 0.73 | ITK (0.44) | HTTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6465833 | 0.73 | ALDH1A1 (0.53) | MEN1KMT2ACA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | HTT 4097/4885MEN1 4599/4885KMT2A 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.