SCHEMBL6507906

SCHEMBL6507906

COC(=O)CC(C)C(=NOCc1ccc(F)cc1)c1ccc(O)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
PPARG P37231 2/20 0.39
PPARA Q07869 2/20 0.39
KMT2A Q03164 2/20 0.39
MAOB P27338 2/20 0.38
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 1/20 0.38
MAPK1 P28482 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
LMNA P02545 2/20 0.36
GAA P10253 1/20 0.36
POLB P06746 1/20 0.36
ESRRB O95718 1/20 0.36
NR4A2 P43354 1/20 0.36
HPGD P15428 1/20 0.36
MME P08473 1/20 0.35
PARP10 Q53GL7 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6505176 0.89 S1PR1 (0.43) S1PR1PPARGPPARAKMT2AMAOB
SCHEMBL6507732 0.88 RAB9A (0.47) SMN1; SMN2PPARGPPARAKMT2AMAOB
SCHEMBL6510873 0.87 PPARG (0.46) S1PR1PPARGPPARAKMT2AMAOB
SCHEMBL6507739 0.87 GRM5 (0.42) PPARGPPARAMAOBMAPTNR4A2
SCHEMBL6533650 0.84 MAOB (0.42) S1PR1SMN1; SMN2MAOBMAPTLMNA
SCHEMBL9734549 0.71 CA1 (0.48) KMT2AALDH1A1MEN1LMNAESRRB
SCHEMBL6506105 0.69 PPARG (0.46) S1PR1SMN1; SMN2PPARGPPARAKMT2A
SCHEMBL17385883 0.69 HTT (0.55) SMN1; SMN2KMT2AALDH1A1MEN1MAPK1
SCHEMBL6155864 0.67 KMT2A (0.48) SMN1; SMN2PPARGKMT2AMAOBALDH1A1
SCHEMBL28200415 0.67 HTT (0.49) KMT2AALDH1A1MEN1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005040127-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2005-05-06 WO disclosed