Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470606 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL6469895 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL6500282 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL6469689 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL6467658 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL6504869 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL6470216 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL6500566 | 0.74 | KDM4E (0.52) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL29719813 | 0.74 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL6498775 | 0.74 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ALDH1A1 846/4885KDM4E 2424/4885HPGD 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.