Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469895 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDHSD17B10NPSR1 | |
| SCHEMBL6498887 | 0.82 | RIPK1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10RIPK1 | |
| Potassium SCHEMBL6498895 | 0.82 | RIPK1 (0.45) | ALDH1A1KDM4EHPGDHSD17B10RIPK1 | |
| Potassium Ion SCHEMBL6498890 | 0.81 | RIPK1 (0.42) | ALDH1A1RIPK1GAA | |
| SCHEMBL14692601 | 0.79 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHPGDHSD17B10PDE4B | |
| SCHEMBL6508436 | 0.78 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL14691494 | 0.77 | PDE4B (0.60) | ALDH1A1PDE4BRIPK1NPSR1PDE4A | |
| SCHEMBL14692586 | 0.76 | HTT (0.64) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL29804250 | 0.76 | HTT (0.64) | ALDH1A1KDM4EHPGDHSD17B10MAPT | |
| SCHEMBL6470606 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ALDH1A1 846/4885KDM4E 2424/4885HPGD 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.