Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 20/20 | 0.76 |
| ▸ | ITGA4 | P13612 | 20/20 | 0.76 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.59 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517864 | 0.92 | ITGB1 (0.63) | ITGB1ITGA4 | |
| SCHEMBL6530242 | 0.88 | ITGA4 (0.73) | ITGB1ITGA4 | |
| SCHEMBL2880989 | 0.87 | ITGB1 (0.74) | ITGB1ITGA4 | |
| SCHEMBL6509079 | 0.86 | ITGB1 (0.84) | ITGB1ITGA4ITGA2ITGB7 | |
| SCHEMBL7261182 | 0.85 | ITGB1 (0.65) | ITGB1ITGA4 | |
| SCHEMBL13913372 | 0.84 | ITGB1 (0.59) | ITGB1ITGA4 | |
| SCHEMBL4316611 | 0.84 | ITGB1 (0.59) | ITGB1ITGA4 | |
| Hydrochloric Acid SCHEMBL5149608 | 0.83 | ITGB1 (0.75) | ITGB1ITGA4 | |
| Hydrochloric Acid SCHEMBL5365851 | 0.82 | ITGB1 (0.78) | ITGB1ITGA4 | |
| SCHEMBL5366055 | 0.82 | ITGA4 (0.64) | ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215598-A1 | Phenylalanine derivatives | CELLTECH R&D LTD. (GB) | 2005-09-29 | — | — | US | disclosed |
| US-6911451-B1 | Phenylalanine derivatives | CELLTECH R&D LIMITED (GB) | 2005-06-28 | — | — | US | disclosed |
| US-20030166691-A1 | Phenylalanine derivatives | ARCHIBALD SARAH CATHERINE (GB) | 2003-09-04 | — | — | US | disclosed |
| US-6555562-B1 | 2-Carboxybenzoyl-(N'-3,5-dichloroisonicotinoyl)-L-4aminophenyl alanine, for example; inhibit the binding of alpha-4 integrins to their ligands, use to treat immune or inflammatory disorders | CELLTECH R&D LIMITED (GB) | 2003-04-29 | — | — | US | disclosed |
| US-20020035127-A1 | Phenylalanine derivatives | CELLTECH THERAPEUTIS, LIMITED | 2002-03-21 | — | — | US | disclosed |
| US-6329372-B1 | HETEROCYCLIC AMIDE COMPOUNDS ARE ABLE TO INHIBIT THE BINDING OF ALPHA4 INTEGRINS TO THEIR LIGANDS AND ARE OF USE IN THE PROPHYLAXIS AND TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS. | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035127-A1 | Phenylalanine derivatives | PAH, VCAM1, IL4I1 | ITGB1 8/4885ITGA4 5/4885ITGA2 35/4885 |
| US-20030166691-A1 | Phenylalanine derivatives | VCAM1, PAH, ITGB4 | ITGB1 6/4885ITGA4 4/4885ITGA2 25/4885 |
| US-20050215598-A1 | Phenylalanine derivatives | PAH, ITGB4, VCAM1 | ITGB1 7/4885ITGA4 4/4885ITGA2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.