Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 11/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506758 | 0.76 | IKBKB (0.50) | MAPTIKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6514861 | 0.73 | DYRK1A (0.52) | MAPTIKBKBJAK2JAK3 | |
| SCHEMBL27570742 | 0.72 | HTR3E (0.69) | HSD17B1HSD17B2HTR3EHTR3BHTR3A | |
| SCHEMBL6507152 | 0.71 | IKBKB (0.57) | TDP1IKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6506340 | 0.69 | FLT3 (0.51) | TDP1MAPTIKBKBJAK2JAK3 | |
| SCHEMBL6505865 | 0.68 | IKBKB (0.58) | TDP1IKBKBJAK2JAK3CHEK1 | |
| SCHEMBL7368760 | 0.68 | HTR3E (0.54) | HSD17B1HSD17B2HTR3EHTR3BHTR3A | |
| SCHEMBL6629827 | 0.68 | HTR3E (0.61) | HSD17B1HSD17B2HTR3EHTR3BHTR3A | |
| SCHEMBL6505484 | 0.68 | CHEK1 (0.55) | TDP1IKBKBJAK2JAK3CHEK1 | |
| SCHEMBL6510565 | 0.68 | MAPK8 (0.65) | TDP1IKBKBJAK2JAK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |