Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499437 | 0.89 | ITK (0.40) | ITKALDH1A1TSHRMAPK10MEN1 | |
| SCHEMBL6467585 | 0.83 | SCN9A (0.44) | ITKALDH1A1TSHRMAPK10MEN1 | |
| SCHEMBL6470268 | 0.81 | ITK (0.42) | ITKALDH1A1TSHRMAPK10MEN1 | |
| SCHEMBL6468065 | 0.81 | ITK (0.43) | ITKALDH1A1TSHRMAPK10MEN1 | |
| SCHEMBL6506609 | 0.80 | ITK (0.49) | ITKALDH1A1AURKAMAPTDGAT1 | |
| SCHEMBL6502983 | 0.80 | ITK (0.41) | ITKALDH1A1TSHRMAPK10 | |
| SCHEMBL6499891 | 0.79 | ITK (0.46) | ITKALDH1A1MAPK10ACACAPOLB | |
| SCHEMBL6507055 | 0.78 | ITK (0.53) | ITKALDH1A1TSHRMAPK10POLB | |
| SCHEMBL6504773 | 0.78 | KDM4E (0.38) | ITKALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6500256 | 0.78 | ITK (0.40) | ITKALDH1A1TSHRMAPK10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885ALDH1A1 846/4885TSHR 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.