Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ATP4A | P20648 | 6/20 | 0.44 |
| ▸ | ATP4B | P51164 | 6/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507782 | 0.86 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL6508538 | 0.83 | RAB9A (0.74) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6518559 | 0.81 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL6507985 | 0.80 | NPC1 (0.47) | SMN1; SMN2KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6511310 | 0.76 | KMT2A (0.54) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL17897822 | 0.76 | LMNA (0.58) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL5923425 | 0.76 | CTNNB1 (0.43) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL6509589 | 0.73 | RAB9A (0.63) | LMNASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6510332 | 0.72 | KMT2A (0.55) | SMN1; SMN2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL31457433 | 0.72 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |