Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATP4A | P20648 | 11/20 | 0.41 |
| ▸ | ATP4B | P51164 | 11/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511304 | 0.85 | MAPT (0.45) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6507318 | 0.84 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6509392 | 0.80 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6510261 | 0.80 | LMNA (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6508538 | 0.79 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6514076 | 0.79 | ADORA2A (0.52) | NPC1RAB9ASMN1; SMN2KMT2AATP4A | |
| SCHEMBL5923387 | 0.77 | ACHE (0.49) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6513739 | 0.76 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5922963 | 0.75 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6508660 | 0.72 | MAPK1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |