Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ATP4A | P20648 | 8/20 | 0.49 |
| ▸ | ATP4B | P51164 | 8/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509589 | 0.90 | RAB9A (0.63) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6510332 | 0.84 | KMT2A (0.55) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6510261 | 0.83 | LMNA (0.52) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6514936 | 0.82 | RAB9A (0.74) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6507568 | 0.81 | RAB9A (0.72) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6507985 | 0.79 | NPC1 (0.47) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2801062 | 0.78 | ADORA2A (0.73) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6513286 | 0.74 | MAPK1 (0.62) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6507406 | 0.74 | RAB9A (0.52) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4101661 | 0.73 | LMNA (0.54) | RAB9AMEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |