Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.54 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.54 |
| ▸ | FEN1 | P39748 | 2/20 | 0.54 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733484 | 0.86 | ERCC1 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 | |
| SCHEMBL10272797 | 0.86 | ERCC1 (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 | |
| SCHEMBL2773897 | 0.85 | ADORA2B (0.59) | ALDH1A1KDM4ESMN1; SMN2ERCC1ERCC5 | |
| SCHEMBL6518727 | 0.84 | FEN1 (0.47) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 | |
| SCHEMBL26606602 | 0.82 | ERCC1 (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 | |
| SCHEMBL23997194 | 0.81 | ERCC5 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 | |
| SCHEMBL2759479 | 0.80 | ERCC1 (0.58) | ALDH1A1KDM4ESMN1; SMN2ERCC1ERCC5 | |
| SCHEMBL24570832 | 0.79 | PARG (0.48) | ALDH1A1KDM4EERCC1ERCC5FEN1 | |
| SCHEMBL210872 | 0.79 | HDAC1 (0.74) | SMN1; SMN2LMNA | |
| SCHEMBL9404614 | 0.75 | FEN1 (0.53) | ALDH1A1KDM4EHPGDSMN1; SMN2ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004126-A1 | Method of determining potential allosterically-binding matrix metalloproteinase inhibitors | ANDRIANJARA CHARLES (FR) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004126-A1 | Method of determining potential allosterically-binding matrix metalloproteinase inhibitors | MMP13, MMP12, MMP25 | ALDH1A1 4241/4885KDM4E 2484/4885HPGD 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.