Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087566 | 0.89 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL14112339 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL10889375 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL30672191 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL19520263 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL107274 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL5599125 | 0.78 | KEAP1 (0.63) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL7581741 | 0.77 | KEAP1 (0.61) | ALDH1A1KEAP1FFAR1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL10803046 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KEAP1FFAR1SMN1; SMN2HDAC2 | |
| SCHEMBL28140267 | 0.76 | MDM2 (0.49) | ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | BENKOVIC STEPHEN J | 2005-10-13 | — | — | US | disclosed |
| US-20040259833-A1 | DNA methyl transferase inhibitors | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2004-12-23 | — | — | US | disclosed |
| EP-1420021-A1 | DNA Methyltransferase inhibitors | The Penn State Research Foundation (US) | 2004-05-19 | — | — | EP | disclosed |
| EP-1181291-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075142-A2 | DNA METHYLTRANSFERASE INHIBITORS | THE PENN STATE RESEARCH FOUNDATION (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | DNMT1, TPMT, GNMT | ALDH1A1 2015/4885KEAP1 1213/4885FFAR1 4059/4885 |
| US-20040259833-A1 | DNA methyl transferase inhibitors | DNMT1, DNMT3A, DIMT1 | ALDH1A1 2274/4885KEAP1 2770/4885FFAR1 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.