Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650385 | 0.90 | ADORA3 (0.36) | ADORA3ADORA2BADORA1MEN1KMT2A | |
| SCHEMBL648999 | 0.90 | ADORA3 (0.37) | ADORA3ADORA2BADORA1MEN1KMT2A | |
| SCHEMBL650059 | 0.89 | AGTR1 (0.37) | ADORA3ADORA2BADORA1AGTR1AGTR2 | |
| SCHEMBL650087 | 0.87 | ADORA3 (0.35) | ADORA3ADORA2BADORA1MEN1KMT2A | |
| SCHEMBL651079 | 0.85 | AGTR1 (0.34) | ADORA3ADORA2BADORA1AGTR1AGTR2 | |
| SCHEMBL651121 | 0.82 | MEN1 (0.34) | ADORA2BMEN1KMT2AAGTR1 | |
| SCHEMBL652331 | 0.82 | DRD2 (0.35) | ADORA2BAGTR1 | |
| SCHEMBL652578 | 0.82 | AGTR1 (0.34) | AGTR1MME | |
| SCHEMBL648189 | 0.81 | DRD2 (0.34) | ADORA2BAGTR1 | |
| SCHEMBL652770 | 0.81 | TLR8 (0.35) | AGTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |